Polyherbal Interventions In Parkinson’s Disease: Mechanistic And Neuroprotective Benefits

Polyherbal Therapy for Parkinsons Disease

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by motor impairment, a decrease in dopamine levels, and oxidative stress. Current therapies primarily alleviate symptoms but has limitations in preventing the progression of the disease. Polyherbal formulations, which consist of various plant extracts, have emerged as promising treatment options due to their synergistic effects in addressing the complex pathology of PD. According to research, employing Polyherbal Formulations (PHFs) that combine several plants can produce better results than using plant extracts alone or their additive effects. This review focuses on the potential mechanisms of action through which PHFs act in treating Parkinson's disease. Additionally, showcasing their therapeutic potential through preclinical and clinical data highlights their efficacy and synergistic qualities. The article explores the neuroprotective advantages emphasizing how well they may treat neuroinflammation, oxidative stress, neurotransmitter modulation, and α-synuclein aggregation mitigation. It emphasizes PHFs importance as supplementary and alternative approaches to controlling neurodegenerative illnesses and explores how they may improve patient outcomes, decrease side effects, and increase therapeutic efficacy. This thorough evaluation highlights the need for additional study to confirm efficacy, improve formulations, and elucidate safety profiles, opening the door to novel, nature-based Parkinson's disease treatment options